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One or more keywords matched the following properties of Kwabi-Addo, Bernard
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overview I am an Associate Professor of Biochemistry and Molecular Biology at Howard University, Washington D.C. I obtained my PhD in Molecular Biology from Queen Mary & Westfield College (University of London, UK) where I carried out studies using Cre-loxP site-specific recombination system to design chromosomal translation in transgenic animal model. I carried out my post-doctoral training at Baylor College of Medicine, Houston TX where I undertook research studies of the molecular mechanisms underlying dys-regulation of receptor tyrosine signaling in prostate cancer. I subsequently joined Howard University cancer Center in 2007 as an Assistant Professor and become an Associate Professor in 2011. Currently, I serve as a Principle Investigator of a prostate cancer research laboratory. The focus of my research is 3 fold: First, to understand the role of epigenetic alterations in regulating gene expression in prostate cancer. Second, to evaluate and implement tools for quantitative DNA methylation analysis in support of differences in prostate cancer tumor biology and prostate cancer disparity and finally, to understand how DNA methylation changes can be explored as potential biomarkers (ethnic sensitive biomarkers) for the early detection of cancer and/or progression of the disease.
One or more keywords matched the following items that are connected to Kwabi-Addo, Bernard
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Academic Article Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer.
Academic Article Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.
Academic Article Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer.
Academic Article Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia.
Academic Article Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer.
Academic Article Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.
Academic Article Correlating blood-based DNA methylation markers and prostate cancer risk in African-American men.
Academic Article Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity.
Academic Article Androgen-induced Epigenetic Profiles of Polycomb and Trithorax Genes in Prostate Cancer Cells.
Academic Article Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer.
Academic Article The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.
Academic Article Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer.
Academic Article FGF-10 is expressed at low levels in the human prostate.
Academic Article Alternative splicing of fibroblast growth factor receptors in human prostate cancer.
Academic Article Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
Academic Article Methionine restriction selectively targets thymidylate synthase in prostate cancer cells.
Academic Article FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia.
Academic Article The role of fibroblast growth factors and their receptors in prostate cancer.
Academic Article Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.
Academic Article Relaxin promotes prostate cancer progression.
Academic Article Age-related DNA methylation changes in normal human prostate tissues.
Academic Article Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Academic Article DNA methylation and aberrant expression of Sprouty1 in human prostate cancer.
Academic Article Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling.
Concept Prostatic Neoplasms
Academic Article Interactions Between Obesity and One-Carbon Metabolism Genes in Predicting Prostate Cancer Outcomes Among White and Black Patients.
Academic Article RASAL2 suppresses the proliferative and invasive ability of PC3 prostate cancer cells.
Academic Article Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer.
Academic Article Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells.
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  • Prostatic Neoplasms
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